Nature Communications | Coronavirus envelope protein activates TMED10-mediated unconventional secretion of inflammatory factors
ABSTRACT: The precise cellular mechanisms underlying heightened proinflammatory cytokine production during coronavirus infection remain incompletely understood. Here we identi…
Congratulations to PhD Student Yuming Zhang for His Achievement in the AI4S Cup!
Recently, PhD student Yuming Zhang won the first prize in the "AI4S Cup – Predicting the Relationship Between Enzyme Function and Mutant Sequences." This competition was joint…
Nature | Molecular basis of human noradrenaline transporter reuptake and inhibition
ABSTRACT: Noradrenaline, also known as norepinephrine, has a wide range of activities and effects on most brain cell types1. Its reuptake from the synaptic cleft heavily relie…
Journal of Chemical Theory and Computation | PointGAT: A Quantum Chemical Property Prediction Model Integrating Graph Attention and 3D Geometry
ABSTRACT: Predicting quantum chemical properties is a fundamental challenge for computational chemistry. While the development of graph neural networks has advanced molecular …
Ph.D. Student Rong Zhang achieved fourth place in the women’s half marathon category at the 2024 Tsinghua University Campus Marathon, ranking first among female participants
In the 2024 Tsinghua University Campus Marathon, doctoral student Rong Zhang, from the 2018 cohort, performed remarkably, achieving fourth place in the women's half marathon c…
Biomacromolecules | Enhancing Protein Solubility via Glycosylation: From Chemical Synthesis to Machine Learning Predictions
ABSTRACT: Glycosylation is a valuable tool for modulating protein solubility; however, the lack of reliable research strategies has impeded efficient progress in understanding…
Briefings in Bioinformatics | Protein-DNA binding sites prediction based on pre-trained protein language model and contrastive learning
ABSTRACT: Protein-DNA interaction is critical for life activities such as replication, transcription, and splicing. Identifying protein-DNA binding residues is essential for m…
eLife | H3-OPT: Accurate prediction of CDR-H3 loop structures of antibodies with deep learning
ABSTRACT: Accurate prediction of the structurally diverse complementarity determining region heavy chain 3 (CDR-H3) loop structure remains a primary and long-standing challeng…
Cell Reports Physical Science | Coupling of alkynes and aryl halides with nickel-catalyzed Sonogashira reactions
ABSTRACT: Methods for incorporating alkynes into molecular skeletons have been the subject of continued research. Compared to the cross-couplings used to form C–C(sp3) and C–C…
