eLife | H3-OPT: Accurate prediction of CDR-H3 loop structures of antibodies with deep learning
ABSTRACT: Accurate prediction of the structurally diverse complementarity determining region heavy chain 3 (CDR-H3) loop structure remains a primary and long-standing challeng…
Cell Reports Physical Science | Coupling of alkynes and aryl halides with nickel-catalyzed Sonogashira reactions
ABSTRACT: Methods for incorporating alkynes into molecular skeletons have been the subject of continued research. Compared to the cross-couplings used to form C–C(sp3) and C–C…
Journal of Virology | Susceptibilities of Human ACE2 Genetic Variants in Coronavirus Infection
ABSTRACT: The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in more than 235 million cases…
Organic Chemistry Frontiers | Elucidating the selectivity of dyotropic rearrangements of β-lactones: a computational survey
ABSTRACT: The dyotropic rearrangement of β-lactones is a neglected treasure in the family of multi-bond reactions and pericyclic reactions. Despite its appealing synthetic pot…
Chemical Science | Controlled movement of ssDNA conjugated peptide through Mycobacterium smegmatis porin A (MspA) nanopore by a helicase motor for peptide sequencing application
ABSTRACT: The lack of an efficient, low-cost sequencing method has long been a significant bottleneck in protein research and applications. In recent years, the nanopore platf…
ACS Catalysis | Diastereo- and Enantioselective Synthesis of Eight-Membered Heterocycles via an Allylation/Ring Expansion Sequence Enabled by Multiple Catalysis
ABSTRACT: The development of protocols for constructing chiral medium-sized heterocycles with high efficiency and excellent stereocontrol is of great interest owing to their u…
Science Immunology | Pharmacological targeting of NLRP3 deubiquitination for treatment of NLRP3-associated inflammatory diseases
ABSTRACT: Pharmacologically inhibiting nucleotide-binding domain and leucine-rich repeat-containing (NLR) family, pyrin domain–containing protein 3 (NLRP3) inflammasome activa…
ACS Catalysis | Cooperative N-heterocyclic Carbene and Iridium Catalysis Enables Stereoselective and Regiodivergent [3 + 2] and [3 + 3] Annulation Reactions
ABSTRACT: A cooperative N-heterocyclic carbene (NHC)/iridium catalysis has been developed to achieve highly stereoselective and regiodivergent [3 + 2] and [3 + 3] annulation r…
